Publikationen
2026
Begutachtete Zeitschriftenartikel
Correlation Between Molecular Genetic Analysis and Nuclear Pleomorphism in Long-Term Recurrent and Metastatic Chordoma[KF1]
S. R. Ullmann, J. Schreier, J. M. Ullmann, M. Georgiades, C. H. Lohmann, M. Röpke, D. Schanze, J. C. A. U. Caputi, S. Franke, F. S. Karras, A. Roessner, Cancers 18 (2026) 898. https://doi.org/10.3390/cancers18060898
Mesothelin in solid tumors: biology, biomarker utility, and therapeutic targeting
I. Ruscito, E. Baisheva, E.T. Taube, E. Ioana Braicu, Current opinion in obstetrics & gynecology 38 (2026) 34–40. https://doi.org/10.1097/GCO.0000000000001083.
Spatial proteomics of ovarian cancer precursors delineates early disease changes and drug targets
A. Makhmut, M.P. Dragomir, S. Fritzsche, M. Moebs, W.D. Schmitt, E.T. Taube, F. Coscia, Molecular Systems Biology 22 (2026) 7–41. https://doi.org/10.1038/s44320-025-00168-4.
2025
Begutachtete Zeitschriftenartikel
Patient-specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
M. Strecker, K. Zohar, M. Böttcher, T. Wartmann, H. Freudenstein, M. Doelling, M. Andric, W. Shi, O. Kakhlon, K. Hippe, B. Jahnke, D. Mougiakakos, F. Baenke, D. Stange, R.S. Croner, M. Linial, U.D. Kahlert, Mol. Oncol. (2025). https://doi.org/10.1002/1878-0261.70129.
A farnesoid X receptor T296I variant disrupts ligand-induced FXR activation and thus bile acid transport in progressive familial intrahepatic cholestasis
A. Behrendt, A. Bastianelli, J. Stindt, E.-D. Pfister, M. Sgodda, T. Cantz, S. Hook, M. Gopalswamy, K. Grau, S. Brands, C. Dröge, A. Stalke, M. Bonus, S. Franke, U. Baumann, V. Keitel, H. Gohlke, J. Biol. Chem. 301 (2025) 110769. https://doi.org/10.1016/j.jbc.2025.110769.
An immunohistochemical and molecular genetic study of 60 colorectal carcinoma brain metastases in pursuit of predictive biomarkers for cancer therapy
J. Lasota, M. Kaczorowski, M. Chłopek, J. Miłek-Krupa, M. Szczepaniak, K. Ylaya, M. Chodyna, E. Iżycka-Świeszewska, A. Scherping, P. Czapiewski, I. Dziuba, Y. Kato, A. Hałoń, A. Kowalik, M. Miettinen, Hum. Pathol. 155 (2025) 105717. https://doi.org/10.1016/j.humpath.2025.105717.
Association between diffusion-weighted imaging and tumor matrix in liver cancer: a cross-sectional study
H.-J. Meyer, J. Potratz, D. Jechorek, K.I. Schramm, J. Borggrefe, A. Surov, Transl. Cancer Res. 14 (2025) 1764–1771. https://doi.org/10.21037/tcr-24-1516.
Association between radiomics of diffusion-weighted imaging and histopathology in hepatocellular carcinoma. A preliminary investigation
H.-J. Meyer, J. Leonhardi, J. Potratz, D. Jechorek, K.I. Schramm, J. Borggrefe, A. Surov, Magnetic Resonance Imaging 118 (2025) 110356. https://doi.org/10.1016/j.mri.2025.110356.
Associations between dynamic-contrast enhanced MRI with histopathological features in atypical HCC using spatial co-registration with biopsy
H.-J. Meyer, J. Potratz, D. Jechorek, K.I. Schramm, J. Borggrefe, A. Surov, Am. J. Transl. Res. 17 (2025) 2967–2975. https://doi.org/10.62347/PJYE7877.
Associations between Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Histopathological Features in Cholangiocarcinoma
H.-J. Meyer, J. Potratz, D. Jechorek, K.I. Schramm, J. Borggrefe, A. Surov, Dig. Dis. 43 (2025) 46–53. https://doi.org/10.1159/000540958.
Evaluating T1/T2 Relaxometry with OCRA Tabletop MRI System in Fresh Clinical Samples: Preliminary Insights into ZEB1-Associated Tissue Characteristics
A.Y. Sanin, M. Prier, T. Wartmann, C. Siba, K. Hippe, M. Pech, R.S. Croner, O. Speck, U.D. Kahlert, G. Rose, Technol. Cancer Res. Treat. 24 (2025) 15330338251366371. https://doi.org/10.1177/15330338251366371.
High expression of the eukaryotic initiation factors eIF4a and eIF4e in retinoblastoma
N. Fischer, A. Schinlauer, P. Czapiewski, Y. Garbers, C. Garbers, Contemp. Oncol. (Pozn) 29 (2025) 257–266. https://doi.org/10.5114/wo.2025.153882.
Immunohistochemical analysis of YB-1 expression in the developing mouse eye
A.F. Nass, H. Wolf, S. Sel, T. Kalinski, N. Nass, Eur. J. Histochem. 69 (2025). https://doi.org/10.4081/ejh.2025.4244.
Transcriptome Analysis of Matched Cohorts of Long-and Short-term Survivors in Advanced High-grade Serous Tubo-ovarian Cancer
S. Marchenko, N. Goernitz, W.A. Zoern, M. Joosten, I. Hoffmann, J. Sehouli, G. Niedobitek, C. Denkert, B.V. Sinn, S. Kolb, J. Carbonell-Caballero, A. Valencia, M.P. Dragomir, W.D. Schmitt, D. Horst, I.I. Braicu, C. Sers, J. Pohl, E.T. Taube, Clinical Cancer Research 31 (2025) 3956–3969. https://doi.org/10.1158/1078-0432.CCR-24-2794.
Mucinous cystic neoplasms of the pancreas and liver share a similar DNA methylation profile with mucinous ovarian tumors
Z. Leoni, T.G. Calina, T. Janik, E. Grafenhorst, E.T. Taube, C.C.M. Neumann, B. Chen, E.I. Braicu, J. Sehouli, T. Malinka, W. Schöning, J. Pratschke, G.A. Calin, D.S. Klimstra, J.K. Benhamida, I. Esposito, M. Möbs, D. Horst, S. Schallenberg, D. Capper, M.P. Dragomir, Journal of Pathology 267 (2025) 10–24. https://doi.org/10.1002/path.6439.
Interleukin-2 receptor α (IL-2Rα/CD25) shedding is differentially regulated by N- and O-glycosylation
A. Franke, S. Dahl, M. Funck, H. Bakker, C. Garbers, J. Lokau, Biochim. Biophys. Acta Mol. Cell Res. 1872 (2025) 119863. https://doi.org/10.1016/j.bbamcr.2024.119863.
Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection
J. Lokau, Y. Garbers, M.M. Vicente, A. Dittrich, S. Meltendorf, H. Lingel, A.K. Münster-Kühnel, M. Brunner-Weinzierl, C. Garbers, Front. Immunol. 15 (2025) 1488745. https://doi.org/10.3389/fimmu.2024.1488745.
Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAM
C. Schwarzenbach, J. Rinke, J.B. Vilar, J. Sallbach, L. Tatsch, A. Schmidt, A. Schöneis, B. Rasenberger, B. Kaina, M.T. Tomicic, M. Christmann, Cell Death Dis 16 (2025) 357. https://doi.org/10.1038/s41419-025-07651-8
Non-Coding RNAs in Diagnostic Pathology of High-Grade Central Osteosarcoma[KF2]
A. Roessner, S. Franke, J. Schreier, S.R. Ullmann, F.S. Karras, Diagnostics (Basel) 15 (2025). https://doi.org/10.3390/diagnostics15111355.
Transcriptome Analysis of Matched Cohorts of Long- and Short-term Survivors in Advanced High-grade Serous Tubo-ovarian Cancer
S. Marchenko, N. Goernitz, W.A. Zoern, M. Joosten, I. Hoffmann, J. Sehouli, G. Niedobitek, C. Denkert, B.V. Sinn, S. Kolb, J. Carbonell-Caballero, A. Valencia, M.P. Dragomir, W.D. Schmitt, D. Horst, I.I. Braicu, C. Sers, J. Pohl, E.T. Taube, Clin. Cancer Res. 31 (2025) 3956–3969. https://doi.org/10.1158/1078-0432.CCR-24-2794.
Transforming growth factor beta induces interleukin-11 expression in osteoarthritis
J. Lokau, M. Bollmann, Y. Garbers, E. Feist, C.H. Lohmann, J. Bertrand, C. Garbers, Cytokine 187 (2025) 156863. https://doi.org/10.1016/j.cyto.2025.156863.
Vision transformer network discovers the prognostic value of pancreatic cancer pathology sections via interpretable risk scores
Z. Peng, Y. Zhang, T. Zhou, W. Shi, Y. Wang, M. Pech, G. Rose, M. Dölling, K. Hippe, R.S. Croner, Y. Zhu, U.D. Kahlert, Discov Onc 16 (2025) 1679. https://doi.org/10.1007/s12672-025-03547-3.
Konferenzbeiträge
Correlating nuclear morphometric patterns with immunohistochemical p53 staining and Ki67 labelling index in sporadic primary and long-term recurring chordomas
Ullmann, Sarah R.; Ullmann, Joana Maria; Schreier, Julian; Georgiades, Marilena; Lohmann, Christoph H.; Röpke, Martin; Karras, Franziska Sabrina; Jechorek, Dörthe; Roessner, Albert; Postervortrag, 37th European Congress of Pathology, Wien, Österreich (37)[KF3]
Virtual H&E staining and computer assisted assessment of lymph node metastases in colorectal carcinoma and neck dissections
A. Eissing-Al-Mukahal, G. Wilkens, V. Q. Tran, V. Kern, M. Rust, N. Farkouh, C. Mogler, L. B. Wilkens; Postervortrag, 37th European Congress of Pathology, Wien, Österreich (37)
Sotorasib plus Panitumumab erzielt klinisches Ansprechen mit lang anhaltender Krankheitskontrolle bei einer Patientin mit refraktärem KRAS G12C-mutiertem Dünndarmkarzinom
K. Bose, V. Keitel-Anselmino, S. Franke, M. Venerito; Postervortrag, 131. Kongress der Deutschen Gesellschaft für Innere Medizin e.V., Wiesbaden (Abstracts zum 131. Kongress der Deutschen Gesellschaft für Innere Medizin e.V. | Die Innere Medizin | Springer Nature Link)
The potential role of keratins and desmosomal proteins in muscle-invasive bladder cancer
A. Scherping, B. Tomasik, J. Luzha, M. Schostak, B. Jandrig, A. Hartmann, N. Abele, M. Eckstein, P. Ströbel, C. Garbers, P. Czapiewski; 108. Jahrestagung der Deutschen Gesellschaft für Pathologie, Leipzig (DGP2025_Book_of_Abstracts_June_10__2025.pdf)
2024
Begutachtete Zeitschriftenartikel
Identifying Truly HPV-Driven Head and Neck Squamous Cell Carcinoma by QuantiGene-Molecular-Profiling-Histology Assay Allows for More Precise Prognosis Prediction
L. Liang, A.E. Albers, E.T. Taube, J. Pohl, S. Schmidt, M. Greve, A.M. Kaufmann, International Journal of Molecular Sciences 25 (2024). https://doi.org/10.3390/ijms252413643.
Characterization of Pleural Mesothelioma by Hierarchical Clustering Analyses Using Immune Cells within Tumor Microenvironment
S. Inaguma, C. Wang, S. Ito, A. Ueki, J. Lasota, P. Czapiewski, R. Langfort, J. Rys, J. Szpor, P. Waloszczyk, K. Okoń, W. Biernat, S. Takiguchi, D.S. Schrump, M. Miettinen, S. Takahashi, , Pathobiology 91 (2024) 313–325. https://doi.org/10.1159/000538520.
Different Forms of TFF3 in the Human Endocervix, including a Complex with IgG Fc Binding Protein (FCGBP), and Further Aspects of the Cervico-Vaginal Innate Immune Barrier
A. Laskou, E.B. Znalesniak, S. Harder, H. Schlüter, D. Jechorek, K. Langer, C. Strecker, C. Matthes, S.N. Tchaikovski, W. Hoffmann, International Journal of Molecular Sciences 25 (2024) 2287. https://doi.org/10.3390/ijms25042287.
DNA methylation classifier to diagnose pancreatic ductal adenocarcinoma metastases from different anatomical sites
T.G. Calina, E. Perez, E. Grafenhorst, J. Benhamida, S. Schallenberg, A. Popescu, I. Koch, T. Janik, B. Chen, J. Ihlow, S. Roessler, B. Goeppert, B. Sinn, M. Bahra, G.A. Calin, E.T. Taube, U. Pelzer, C.C.M. Neumann, D. Horst, E. Knutsen, D. Capper, M.P. Dragomir, Clinical Epigenetics 16 (2024). https://doi.org/10.1186/s13148-024-01768-x.
Downregulation of the keratins CK13 and CK14 does not significantly affect cell viability of human urinary bladder carcinoma cells
A. Scherping, A. Schinlauer, P. Czapiewski, C. Garbers, Contemp. Oncol. (Pozn) 28 (2024) 227–234. https://doi.org/10.5114/wo.2024.144215.
Molecular characterization of the craniosynostosis-associated interleukin-11 receptor variants p.T306_S308dup and p.E364_V368del
B. Kespohl, A.-L. Hegele, S. Düsterhöft, H. Bakker, F.F.R. Buettner, R. Hartig, J. Lokau, C. Garbers, The FEBS Journal 291 (2024) 1667–1683. https://doi.org/10.1111/febs.17015.
MRI analysis of relative tumor enhancement in liver metastases and correlation with immunohistochemical features
F. Barajas Ordonez, S. Gottschling, K.I. Eger, J. Borggrefe, D. Jechorek, A. Surov, Insights Imaging 15 (2024) 294. https://doi.org/10.1186/s13244-024-01866-7.
Patient-derived melanoma models
F. Karras, M. Kunz, Pathol. Res. Pract. 259 (2024) 155231. https://doi.org/10.1016/j.prp.2024.155231.
Surgical Outcome and Microbial Colonization of Standardized Smear Locations after Pancreatic Head Resection (Pylorus-Preserving Pancreatoduodenectomy, PPPD) for Chronic Pancreatitis and Pancreatic Head Carcinoma
M. Grabowski, R. Otto, I. Tammer, D. Jechorek, H. Ptok, S. Al-Madhi, R. Croner, F. Meyer, Journal of Clinical Medicine 13 (2024) 3810. https://doi.org/10.3390/jcm13133810.
Sustained Clinical Response to Ivosidenib in Previously Treated Patients with Advanced Intrahepatic Cholangiocarcinoma Harboring an IDH1 R132 Mutation: Two Case Reports
C. Müller, S. Franke, T. Reisländer, V. Keitel, M. Venerito, Case Rep Oncol 17 (2024) 753–762. https://doi.org/10.1159/000539665.
The role of interleukin-6 classic and trans-signaling and interleukin-11 classic signaling in gastric cancer cells
J. Runge, C. Garbers, J. Lokau, Contemp. Oncol. (Pozn) 28 (2024) 105–113. https://doi.org/10.5114/wo.2024.142211.
The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function
J. Lokau, L.M. Petasch, C. Garbers, Immunology 171 (2024) 377–387. https://doi.org/10.1111/imm.13723.
Gene expression markers in peripheral blood and outcome in patients with platinum-resistant ovarian cancer: A study of the European GANNET53 consortium
E. Obermayr, T. Mohr, E. Schuster, E.I. Braicu, E. Taube, J. Sehouli, I. Vergote, E. Pujade-Lauraine, I. Ray-Coquard, P. Harter, P. Wimberger, F. Joly-Lobbedez, S. Mahner, U.M. Moll, N. Concin, R. Zeillinger, International Journal of Cancer 155 (2024) 1128–1138. https://doi.org/10.1002/ijc.34978.
Tumorläsion des Pankreas mit unklarer Dignität
K. Dossow, S. Acciuffi, C. March, D. Jechorek, R.S. Croner, F. Meyer, S. Al-Madhi, Chirurgie 95 (2024) 841–846. https://doi.org/10.1007/s00104-024-02132-8.
Uncommon diagnosis of multinodular goiter - isolated extrapulmonary manifestation of sarcoidosis in thyroid gland (scientific case reports)
M. Neumann, F. Meyer, T. Oksentyuk Polyakova, U. Barth, D. Jechorek, R.S. Croner, M. Petersen, Pathol. Res. Pract. 256 (2024) 155235. https://doi.org/10.1016/j.prp.2024.155235.
Strain specific differences in vitamin D3 response: impact on gut homeostasis
L. Schreiber, S. Ghimire, A. Hiergeist, K. Renner, M. Althammer, N. Babl, A. Peuker, G. Schoenhammer, K. Hippe, A. Gessner, C. Albrecht, F. Pielmeier, M. Büttner-Herold, H. Bruns, P. Hoffmann, W. Herr, E. Holler, K. Peter, M. Kreutz, C. Matos, Front. Immunol. 15 (2024) 1347835. https://doi.org/10.3389/fimmu.2024.1347835.
AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication
N. Monjé, M.P. Dragomir, B.V. Sinn, I. Hoffmann, A. Makhmut, T. Simon, C.A. Kunze, J. Ihlow, W.D. Schmitt, J. Pohl, I. Piwonski, S. Marchenko, C. Keunecke, T.G. Calina, F. Tiso, H. Kulbe, C. Kreuzinger, D. Cacsire Castillo-Tong, J. Sehouli, E.I. Braicu, C. Denkert, S. Darb-Esfahani, K. Kübler, D. Capper, F. Coscia, M. Morkel, D. Horst, C. Sers, E.T. Taube, British Journal of Cancer 130 (2024) 1249–1260. https://doi.org/10.1038/s41416-023-02550-1.
Utility of Immunohistochemistry With Antibodies to SS18-SSX Chimeric Proteins and C-Terminus of SSX Protein for Synovial Sarcoma Differential Diagnosis
J. Lasota, M. Chłopek, M. Kaczorowski, K. Natálie, J. Ryś, J. Kopczyński, O. Sulaieva, M. Michal, A. Kruczak, A. Harazin-Lechowska, M. Szczepaniak, O. Koshyk, A. Hałoń, P. Czapiewski, Z. Abdullaev, A. Kowalik, K.D. Aldape, M. Michal, M. Miettinen, The American Journal of Surgical Pathology 48 (2024) 97–105. https://doi.org/10.1097/PAS.0000000000002144.
Konferenzbeiträge
Integrated genomic and epigenetic analysis of matched primary and metastatic highly malignant osteosarcoma[KF4]
F. S. Karras, A. Roessner, C. Schmidt, S. Franke, D. Jechorek; Plattform-Vortrag, USCAP 113th Annual Meeting, Baltimore, MD, USA; Plattform-Vortrag, DGP 107. Jahrestagung, München; Postervortrag, 36. Deutscher Krebskongress, Berlin
microRNA profiling in combination with whole exome sequencing reveals insights into long-term recurrence patterns in chordoma[KF5]
S. R. Ullmann; F. Karras; J. Schreier; Kerstin Körber-Ferl; David A. Ullmann; S. Franke; A. Roessner; D. Jechorek; Plattform-Vortrag, DGP 107. Jahrestagung, München; Postervortrag, AACR Annual Meeting, San Diego, CA, USA; Postervortrag, 36. Deutscher Krebskongress, Berlin (Abstract 5057: microRNA profiling in combination with whole exome sequencing reveals insights into long-term recurrence patterns in chordoma | Cancer Research | American Association for Cancer Research)
The BMP/TGF-β signaling in the development of dedifferentiated chondrosarcoma[KF6]
F. S. Karras, J. Schreier, S. R. Ullmann, S. Franke, K. Körber-Ferl, D. Jechorek, A. Roessner; Postervortrag, 36. Deutscher Krebskongress, Berlin; Postervortrag, DGP 107. Jahrestagung, München
TGF-beta Pseudorezeptor BAMBI als Therapieziel im Pankreastumor
P. Winter, T. Wartmann, K. Hippe, L. Wilkens, R. Croner, U. Kahlert; Postervortrag, DGVS & DGAV Jahreskongress, Leipzig (Thieme E-Journals - Zeitschrift für Gastroenterologie / Abstract)
Paraplegia and bone marrow failure due to poorly differentiated metastatic colon cancer effectively treated with FOLFOX/bevacizumab
C. Müller, E. Schalk, K. Hauptmann, C. Mawrin, D. Medenwald, K.-P. Stein, C. Franck, V. Keitel-Anselmino, M. Venerito; Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Hämatologie und Medizinische Onkologie, Basel, Schweiz https://doi.org/10.1159/000540557
Schilddrüsenabszess - ungewöhnliche und seltene Diagnose bei einer Patientin mit starkem rechtsseitigen Druckschmerz am Hals und Schluckbeschwerden
F. Al-Qahom, F. Meyer, A. Rose, S. Al-Madhi, C. A. L. March, D. Jechorek, R. Croner, M. Petersen; 130. Kongress der Deutschen Gesellschaft für Innere Medizin e.V., Wiesbaden (Abstracts zum 130. Kongress der Deutschen Gesellschaft für Innere Medizin e.V. | Die Innere Medizin | Springer Nature Link)
2023
Begutachtete Zeitschriftenartikel
Akute Appendagitis epiploica – seltene Differenzialdiagnose des akuten Abdomens
L. Harling, S. Peglow, K. Eger, C. March, R.S. Croner, F. Meyer, Z Gastroenterol 61 (2023) 172–177. https://doi.org/10.1055/a-1727-9842.
Apparent diffusion coefficient correlates with different histopathological features in several intrahepatic tumors
A. Surov, K.I. Eger, J. Potratz, S. Gottschling, A. Wienke, D. Jechorek, Eur Radiol 33 (2023) 5955–5964. https://doi.org/10.1007/s00330-023-09788-6.
LRP1B—a prognostic marker in tubo-ovarian high-grade serous carcinoma
S. Kolb, I. Hoffmann, N. Monjé, M.P. Dragomir, P. Jank, P. Bischoff, C. Keunecke, J. Pohl, C.A. Kunze, S. Marchenko, W.D. Schmitt, H. Kulbe, C. Sers, J. Sehouli, E.I. Braicu, C. Denkert, S. Darb-Esfahani, D. Horst, B.V. Sinn, E.T. Taube, Hum. Pathol. 141 (2023) 158–168. https://doi.org/10.1016/j.humpath.2023.09.001.
Intestinal IgA-positive plasma cells are highly sensitive indicators of alloreaction early after allogeneic transplantation and associate with both graft-versus-host disease and relapse-related mortality
L. Scheidler, K. Hippe, S. Ghimire, D. Weber, M. Weber, E. Meedt, P. Hoffmann, P. Lehn, R. Burkhardt, A. Mamilos, M. Edinger, D. Wolff, H. Poeck, M. Evert, A. Gessner, W. Herr, E. Holler, Haematologica 108 (2023) 2993–3000. https://doi.org/10.3324/haematol.2022.282188.
Cardioprotective Effects of Dexmedetomidine in an Oxidative-Stress In Vitro Model of Neonatal Rat Cardiomyocytes
M. Borger, C. von Heafen, C. Bührer, S. Endesfelder, Antioxidants 12 (2023) 1206. https://doi.org/10.3390/antiox12061206
Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer
I. Hoffmann, M.P. Dragomir, N. Monjé, C. Keunecke, C.A. Kunze, S. Schallenberg, S. Marchenko, W.D. Schmitt, H. Kulbe, J. Sehouli, I.E. Braicu, P. Jank, C. Denkert, S. Darb-Esfahani, D. Horst, B.V. Sinn, C. Sers, P. Bischoff, E.T. Taube, Neoplasia (United States) 44 (2023). https://doi.org/10.1016/j.neo.2023.100934.
CD70 and PD-L1 (CD274) co-expression predicts poor clinical outcomes in patients with pleural mesothelioma
S. Inaguma, A. Ueki, J. Lasota, M. Komura, A.N. Sheema, P. Czapiewski, R. Langfort, J. Rys, J. Szpor, P. Waloszczyk, K. Okoń, W. Biernat, D.S. Schrump, R. Hassan, M. Miettinen, S. Takahashi, The Journal of Pathology: Clinical Research 9 (2023) 195–207. https://doi.org/10.1002/cjp2.310.
Coding variants of the interleukin-11 receptor with reduced protein maturation show protease-dependent trans-signaling and transduce normal STAT3 signaling
B. Kespohl, R. Hartig, Y. Garbers, J. Lokau, C. Garbers, Genes & Diseases 10 (2023) 373–376. https://doi.org/10.1016/j.gendis.2022.05.001.
Comparative analysis of miRNA expression in dedifferentiated and well-differentiated components of dedifferentiated chondrosarcoma[KF7]
F.S. Karras, J. Schreier, K. Körber-Ferl, S.R. Ullmann, S. Franke, A. Roessner, D. Jechorek, Pathol. Res. Pract. 244 (2023) 154414. https://doi.org/10.1016/j.prp.2023.154414.
Prognostic value of regulatory T cells and T helper 17 cells in high grade serous ovarian carcinoma
S. Marchenko, I. Piwonski, I. Hoffmann, B.V. Sinn, C.A. Kunze, N. Monjé, J. Pohl, H. Kulbe, W.D. Schmitt, S. Darb-Esfahani, E.I. Braicu, A.-C. von Brünneck, J. Sehouli, C. Denkert, D. Horst, K. Jöhrens, E.T. Taube, J Cancer Res Clin Oncol 149 (2023) 2523–2536. https://doi.org/10.1007/s00432-022-04101-2.
Decreased eukaryotic initiation factors expression upon temozolomide treatment-potential novel implications for eIFs in glioma therapy
S. Krassnig, S.L. Leber, A. Orthmann, N. Golob-Schwarzl, H.J. Huber, C. Wohlrab, C. Skofler, M. Pennauer, A. Raicht, A.M. Birkl-Toeglhofer, M. Naumann, K. Mahdy-Ali, G. von Campe, M. Leoni, J. Alcaniz, J. Hoffmann, T. Wälchli, S. Weis, M. Benesch, J. Haybaeck, J Neurooncol 165 (2023) 91–100. https://doi.org/10.1007/s11060-023-04451-y.
Factors Affecting Performance of DNA Methylation as a Potential Biomarker in Ascites for Peritonitis and Peritoneal Carcinomatosis
K. Bose, F.G. Scurt, C. Thon, S. Franke, C. Schulz, P. Malfertheiner, A. Link, JGLD 32 (2023) 206–215. https://doi.org/10.15403/jgld-4710.
Round-Robin test for the histological diagnosis of acute colonic Graft-versus-Host disease validating established histological criteria and grading systems
K. Hippe, A. Kreft, S. Reu-Hofer, A. Rosenwald, F. Ferrazzi, C. Daniel, K. Amann, S. Kraus, E. Holler, A. Kandulski, D. Hirsch, A. Buttner, W. Rösler, K. Hildner, J. Winkler, M. Büttner-Herold, Virchows Arch 483 (2023) 47–58. https://doi.org/10.1007/s00428-023-03544-3.
JNKs protect from cholestatic liver disease progression by modulating Apelin signalling
M.R. Mohamed, J. Haybaeck, H. Wu, H. Su, M. Bartneck, C. Lin, M.V. Boekschoten, P. Boor, B. Goeppert, C. Rupp, P. Strnad, R.J. Davis, F.J. Cubero, C. Trautwein, JHEP Reports 5 (2023) 100854. https://doi.org/10.1016/j.jhepr.2023.100854.
Prognostic impact of variant histologies in urothelial bladder cancer treated with radical cystectomy
F. Claps, M.W. van de Kamp, R. Mayr, P.J. Bostrom, S.F. Shariat, K. Hippe, S. Bertz, Y. Neuzillet, J. Sanders, W. Otto, M.S. van der Heijden, M.A.S. Jewett, R. Stöhr, A.R. Zlotta, C. Trombetta, M. Eckstein, L.S. Mertens, M. Burger, Y. Soorojebally, B. Wullich, R. Bartoletti, F. Radvanyi, N. Pavan, N. Sirab, M.C. Mir, D. Pouessel, T.H. van der Kwast, A. Hartmann, Y. Lotan, R. Bussani, Y. Allory, B.W.G. van Rhijn, BJU Int. 132 (2023) 170–180. https://doi.org/10.1111/bju.15984.
High EVI1 and PARP1 expression as favourable prognostic markers in high-grade serous ovarian carcinoma
P. Jank, J. Leichsenring, S. Kolb, I. Hoffmann, P. Bischoff, C.A. Kunze, M.P. Dragomir, M. Gleitsmann, M. Jesinghaus, W.D. Schmitt, H. Kulbe, C. Sers, A. Stenzinger, J. Sehouli, I.E. Braicu, C. Westhoff, D. Horst, C. Denkert, S. Gröschel, E.T. Taube, Journal of Ovarian Research 16 (2023). https://doi.org/10.1186/s13048-023-01239-6.
Laparoscopic cholecystectomy for symptomatic cholecystolithiasis (CCL) in "Kasabach-Merritt syndrome" (KMS) (Kaposi-tumor like hemangioendothelioma with case-specific perioperative management)
S. Arndt, C. Wex, I. Häusler-Pliske, D. Jechorek, H. Krause, Z. Halloul, F. Meyer, Innovative Surgical Sciences 8 (2023) 113–117. https://doi.org/10.1515/iss-2022-0017.
Ligandrol-induzierte toxische Hepatopathie – ein Fallbericht
F. Wallstab, D. Jechorek, V. Keitel-Anselmino, U. von Arnim, , Z Gastroenterol 61 (2023) 522–525. https://doi.org/10.1055/a-1886-4666.
Manifestation of acute appendicitis as known but paradox visceral side effect of ulcerative colitis anti-inflammatory therapy with januskinase-inhibitor Tofacitinib (Xeljanz™)
F. Weber, K.I. Eger, C. March, R.S. Croner, F. Meyer, Pathol. Res. Pract. 248 (2023) 154333. https://doi.org/10.1016/j.prp.2023.154333.
MEK inhibition induces expression of differentiation marker Keratin 10 in human keratinocytes
F. Karras, M. Bonsack, S. Seifert, L. Friedrich, M. Kunz, Pathol. Res. Pract. 250 (2023) 154788. https://doi.org/10.1016/j.prp.2023.154788.
Mismatch repair deficiency, chemotherapy and survival for resectable gastric cancer: an observational study from the German staR cohort and a meta-analysis
T. Stolze, S. Franke, J. Haybaeck, M. Moehler, P.P. Grimminger, H. Lang, W. Roth, I. Gockel, N. Kreuser, H. Bläker, C. Wittekind, F. Lordick, M. Vieth, L. Veits, O. Waidmann, P. Lingohr, U. Peitz, C. Schildberg, M. Kruschewski, N. Vassos, E. Goni, C.J. Bruns, K. Ridwelski, S. Wolff, H. Lippert, J. Schumacher, P. Malfertheiner, M. Venerito, J Cancer Res Clin Oncol 149 (2023) 1007–1017. https://doi.org/10.1007/s00432-022-03953-y.
No association of malignant B-cell non-Hodgkin lymphomas with ipsilateral SARS-CoV-2 vaccination
L.V. Claaß, P. Mayr, L. Paschold, T. Weber, D. Terziev, B. Jehs, R. Brill, J. Dober, B. Märkl, C. Wickenhauser, P. Czapiewski, M. Trepel, R. Claus, M. Binder, Cancer Medicine 12 (2023) 9313–9321. https://doi.org/10.1002/cam4.5687.
Targeting IL-6 trans-signalling: past, present and future prospects
S. Rose-John, B.J. Jenkins, C. Garbers, J.M. Moll, J. Scheller, Nat Rev Immunol 23 (2023) 666–681. https://doi.org/10.1038/s41577-023-00856-y.
The Search for the Optimal cut-off Value of p53-Immunohistochemistry to Predict Prognosis of Invasive Bladder Cancer: A Multi-Center
L.S. Mertens, F. Claps, R. Mayr, A. Hodgson, S.F. Shariat, K. Hippe, Y. Neuzillet, J. Sanders, M. Burger, D. Pouessel, W. Otto, T.H. van der Kwast, Y. Lotan, Y. Allory, M.R. Downes, B.W.G. van Rhijn, Multi-Laboratory Analysis, Int. J. Surg. Pathol. 31 (2023) 157–166. https://doi.org/10.1177/10668969221095173.
The interleukin-11 receptor variant p.W307R results in craniosynostosis in humans
I. Ahmad, J. Lokau, B. Kespohl, N.A. Malik, S.M. Baig, R. Hartig, D. Behme, R. Schwab, J. Altmüller, M. Jameel, S. Mucha, H. Thiele, M. Tariq, P. Nürnberg, J. Erdmann, C. Garbers, Sci Rep 13 (2023) 13479. https://doi.org/10.1038/s41598-023-39466-y.
Konferenzbeiträge
Genomic evolution of recurrence development in chordoma - a whole exome study comparing primary tumors and long-term recurrences
S. Ullmann, A. Roessner, D. Jechorek, J. Schreier, S. Franke, F. S. Karras; Plattform-Vortrag, USCAP 112th Annual Meeting, New Orleans, LA, USA[KF8]
Imatinib induces clinical response in a patient with refractory combined hepatocellular and cholangiocellular carcinoma harbouring a rare PDGFRA exon 18 mutation (p.I843_S847delinsT)
C. Müller, S. Franke, D. Jechorek, J. Omari, V. Keitel-Anselmino, M. Venerito; Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaft für Hämatologie und Medizinische Onkologie, Hamburg
Dependence of pathogenic T helper cells on lipid receptors during house dust mite allergic airway inflammation
A. Krone, S. Schreiber, J. Negele, T. Franz, J. Kotrba, A. Marks, M. Roder, A. Sammt, N. Jantz-Naeem, C. Garbers, R. Geffers, B. Schraven, A. J. Müller, A. Dudeck, S. Kahlfuß; Joint Conference of the Société Francais d’Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DgfI), Strasbourg, Frankreich (Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), 26–29 September, 2023, Strasbourg, France - 2023 - European Journal of Immunology - Wiley Online Library)
Epigenetic training of the interleukin 6 gene in airway epithelial cells is central to asthma exacerbations
L. Lunding, M. Weckmann, U. Zißler, R. Bodenstein-Sgró, S. Webering, R. F. Ceballos, S. Nemani, B. Oliver, C. Vermeulen, M. Berge, C. Ober, A. Kuenstner, H. Busch, I. R. König, C. Garbers, C. B. Schmidt-Weber, A. Ö. Yildirim, T. Bahmer, G. Hansen, E. von Mutius, K. F. Rabe, A.-M. Dittrich, B. Schaub, M. V. Kopp, M. Wegmann; American Thoracic Society International Conference, Washington D.C., MA, USA (Epigenetic Training of the Interleukin 6 Gene in Airway Epithelial Cells Is Central to Asthma Exacerbations | A101. LINKING BIOLOGY TO THE REAL WORLD IN ASTHMA AND ALLERGIC INFLAMMATION)
Koinzidenz von drei Karzinomen des Magen-Darm-Traktes an verschiedenen Segmenten
Y. Zaporozhchenko, D. Jechorek, C. A. L. March, R. Croner, F. Meyer; 129. Kongress der Deutschen Gesellschaft für Innere Medizin e.V. (Abstracts zum 129. Kongress der Deutschen Gesellschaft für Innere Medizin e.V. | Die Innere Medizin | Springer Nature Link)
Selective blockade of human ILinduced trans-signaling with novel anti-ILReceptor antibodies
E. Rieneck, R. Haak, K. Asgarov, J.-R. Pallandre, N. Wundrack, S.-M. Küllmey, C. Garbers, A. Clark, J. Wijdenes, F. Schaper, A. Dittrich; 26th Meeting on Signal Transduction, Weimar
2022
Begutachtete Zeitschriftenartikel
Anti-IL-6 cytokine treatment has no impact on elevated hematocrit or splenomegaly in a polycythemia vera mouse model
C.K. Baldauf, P. Müller, T.R. Haage, S. Adam-Frey, J. Lokau, C. Garbers, T. Fischer, Blood Adv 6 (2022) 399–404. https://doi.org/10.1182/bloodadvances.2021004379.
Autoimmungastritis
M. Venerito, S. Sulzer, D. Jechorek, Dtsch Med Wochenschr 147 (2022) 451–459. https://doi.org/10.1055/a-1520-3562.
BCL3 expression is strongly associated with the occurrence of breast cancer relapse under tamoxifen treatment in a retrospective cohort study
P. Czapiewski, M. Cornelius, R. Hartig, T. Kalinski, J. Haybaeck, A. Dittmer, J. Dittmer, A. Ignatov, N. Nass, Virchows Arch 480 (2022) 529–541. https://doi.org/10.1007/s00428-021-03238-8.
Case Report: Arterial Wall Inflammation in Atherosclerotic Cardiovascular Disease is Reduced by Olamkicept (sgp130Fc)
D.M. Schulte, G.H. Waetzig, H. Schuett, M. Marx, B. Schulte, C. Garbers, J. Lokau, A.-K. Vlacil, J. Schulz, A.K. Seoudy, B. Schieffer, P. Rosenstiel, M. Seeger, M. Laudes, S. Rose-John, U. Lützen, K. Grote, S. Schreiber, Front. Pharmacol. 13 (2022) 758233. https://doi.org/10.3389/fphar.2022.758233.
Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer: A Multicenter Retrospective Study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium
J. Glajzer, D.C. Castillo-Tong, R. Richter, I. Vergote, H. Kulbe, A. Vanderstichele, I. Ruscito, F. Trillsch, A. Mustea, C. Kreuzinger, C. Gourley, H. Gabra, E.T. Taube, O. Dorigo, D. Horst, C. Keunecke, J. Baum, T. Angelotti, J. Sehouli, E.I. Braicu, Annals of Surgical Oncology 30 (2023) 35–45. https://doi.org/10.1245/s10434-022-12459-3.
Low Expression of RGS2 Promotes Poor Prognosis in High-Grade Serous Ovarian Cancer
J. Ihlow, N. Monjé, I. Hoffmann, P. Bischoff, B.V. Sinn, W.D. Schmitt, C.A. Kunze, S. Darb-Esfahani, H. Kulbe, E.I. Braicu, J. Sehouli, C. Denkert, D. Horst, E.T. Taube, Cancers 14 (2022). https://doi.org/10.3390/cancers14194620.
Differential Expression of Long Noncoding RNA HOTAIR in Intestinal Metaplasia and Gastric Cancer
V. Petkevicius, C. Thon, R. Steponaitiene, J. Skieceviciene, D. Janciauskas, D. Jechorek, P. Malfertheiner, J. Kupcinskas, A. Link, Clinical and Translational Gastroenterology 13 (2022) e00483. https://doi.org/10.14309/ctg.0000000000000483.
Eosinophile Ösophagitis: Vergleich klinischer, endoskopischer und histologischer Scoringsysteme
N.J. Lorenz, A. Link, P. Czapiewski, U. von Arnim, Z Gastroenterol 60 (2022) 1779–1786. https://doi.org/10.1055/a-1855-1974.
Fatal course of a benign mediastinal lipoblastoma in a 20-year-old woman
C. Ganzert, A. Popov, E. Lücke, S. Franke, D. Jechorek, M. Zenker, T. Walles, M. Pech, J. Schreiber, Pathol. Res. Pract. 239 (2022) 154161. https://doi.org/10.1016/j.prp.2022.154161.
Predictive biomarker for surgical outcome in patients with advanced primary high-grade serous ovarian cancer. Are we there yet? An analysis of the prospective biobank for ovarian cancer
C. Keunecke, H. Kulbe, F. Dreher, E.T. Taube, R. Chekerov, D. Horst, M. Hummel, T. Kessler, K. Pietzner, W. Kassuhn, F. Heitz, M.Z. Muallem, S.M. Lang, I. Vergote, O. Dorigo, H. Lammert, A. Du Bois, T. Angelotti, C. Fotopoulou, J. Sehouli, E.I. Braicu, Gynecologic Oncology 166 (2022) 334–343. https://doi.org/10.1016/j.ygyno.2022.06.010.
Function and proteolytic generation of the soluble interleukin-6 receptor in health and disease
T. Schumertl, J. Lokau, S. Rose-John, C. Garbers, Biochim. Biophys. Acta Mol. Cell Res. 1869 (2022) 119143. https://doi.org/10.1016/j.bbamcr.2021.119143.
Genetics and epigenetics in conventional chondrosarcoma with focus on non-coding RNAs[KF9]
A. Roessner, S. Franke, J. Schreier, S. Ullmann, F. Karras, D. Jechorek, Pathol. Res. Pract. 239 (2022) 154172. https://doi.org/10.1016/j.prp.2022.154172.
Identification of IL-6 Signalling Components as Predictors of Severity and Outcome in COVID-19
M.Á. Rodríguez-Hernández, D. Carneros, M. Núñez-Núñez, R. Coca, R. Baena, G.M. López-Ruiz, M.E. Cano-Serrano, A. Martínez-Tellería, A. Fuentes-López, J.M. Praena-Fernandez, C. Garbers, J. Hernández-Quero, F. García, S. Rose-John, M. Bustos, Front. Immunol. 13 (2022) 891456. https://doi.org/10.3389/fimmu.2022.891456.
Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc
A. Krone, Y. Fu, S. Schreiber, J. Kotrba, L. Borde, A. Nötzold, C. Thurm, J. Negele, T. Franz, S. Stegemann-Koniszewski, J. Schreiber, C. Garbers, A. Shukla, R. Geffers, B. Schraven, D. Reinhold, A. Dudeck, A. Reinhold, A.J. Müller, S. Kahlfuss, Sci Rep 12 (2022) 1943. https://doi.org/10.1038/s41598-022-04827-6.
The collectrin‐like part of the SARS‐CoV‐1 and ‐2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17
R.V. Niehues, J. Wozniak, F. Wiersch, E. Lilienthal, N. Tacken, T. Schumertl, C. Garbers, A. Ludwig, S. Düsterhöft, The FASEB Journal 36 (2022) e22234. https://doi.org/10.1096/fj.202101521R.
Polycomb Protein BMI-1 as a Potential Therapeutic Target in Mucinous Ovarian Cancer
S. Abobaker, H. Kulbe, E.T. Taube, S. Darb-Esfahani, R. Richter, C. Denkert, P. Jank, J. Sehouli, E.I. Braicu, Anticancer Research 42 (2022) 1739–1747. https://doi.org/10.21873/anticanres.15650.
The influence of gastric atrophy on Helicobacter pylori antibiotics resistance in therapy-naïve patients
E. Goni, I. Tammer, K. Schütte, C. Thon, D. Jechorek, U.M. Mahajan, R. Vasapolli, L. Macke, B. Aulinger, M. Selgrad, A. Link, P. Malfertheiner, C. Schulz, Front. Microbiol. 13 (2022) 938676. https://doi.org/10.3389/fmicb.2022.938676.
Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients
L.S. Mertens, F. Claps, R. Mayr, P.J. Bostrom, S.F. Shariat, E.C. Zwarthoff, J.L. Boormans, C. Abas, G.J.L.H. van Leenders, S. Götz, K. Hippe, S. Bertz, Y. Neuzillet, J. Sanders, A. Broeks, D. Peters, M.S. van der Heijden, M.A.S. Jewett, R. Stöhr, A.R. Zlotta, M. Eckstein, Y. Soorojebally, D.K.E. van der Schoot, B. Wullich, M. Burger, W. Otto, F. Radvanyi, N. Sirab, D. Pouessel, T.H. van der Kwast, A. Hartmann, Y. Lotan, Y. Allory, T.C.M. Zuiverloon, B.W.G. van Rhijn, Urol. Oncol. 40 (2022) 110.e1-110.e9. https://doi.org/10.1016/j.urolonc.2021.10.010.
The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo
S. Kirschke, I. Ogunsulire, B. Selvakumar, N. Schumacher, T. Sezin, S. Rose-John, A. Scheffold, C. Garbers, J. Lokau, J. Biol. Chem. 298 (2022) 101910. https://doi.org/10.1016/j.jbc.2022.101910.
The role of proteolysis in interleukin-11 signaling
J. Lokau, B. Kespohl, S. Kirschke, C. Garbers, Biochim. Biophys. Acta Mol. Cell Res. 1869 (2022) 119135. https://doi.org/10.1016/j.bbamcr.2021.119135.
The tamoxifen-regulated, long non-coding RNA LINC00992 affects proliferation, migration, and expression of tamoxifen resistance-associated genes in MCF-7 breast cancer cells
S. Graf, J. Haybaeck, G. Behre, T. Kalinski, N. Nass, Contemp. Oncol. (Pozn) 26 (2022) 294–305. https://doi.org/10.5114/wo.2023.125000.
In Situ N-Glycosylation Signatures of Epithelial Ovarian Cancer Tissue as Defined by MALDI Mass Spectrometry Imaging
M. Grzeski, E.T. Taube, E.I. Braicu, J. Sehouli, V. Blanchard, O. Klein, Cancers 14 (2022). https://doi.org/10.3390/cancers14041021.
Tumor Budding Is an Independent Prognostic Factor in Pancreatic Adenocarcinoma and It Positively Correlates with PD-L1 Expression on Tumor Cells
R. Pęksa, M. Kunc, P. Czapiewski, M. Piątek, S. Hać, B. Radecka, W. Biernat, Biomedicines 10 (2022). https://doi.org/10.3390/biomedicines10071761.
Konferenzbeiträge
Whole exome sequencing analysis of dedifferentiated chondrosarcoma[KF10]
J. Schreier, A. Roessner, S. R. Ullmann, D. Schanze, D. Jechorek, S. Franke; 105. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster (Microsoft Word - DGP2022_Abstractband_Impressum); 34th European Congress of Pathology, Basel, Schweiz (34th European Congress of Pathology - Abstracts | Virchows Archiv | Springer Nature Link)
Adrenocortical carcinoma (ACC) in an infant with Cushing's syndrome and virilization
S. Turial, H. Krause, F. Meyer, M. Zenker, D. Jechorek, A. K. Redlich; 105. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster (Microsoft Word - DGP2022_Abstractband_Impressum)
Lipoblastoma as a representative example of rare soft tissue tumor lesions in infants with its challenging diagnostic and surgical management
S. Turial, H. Krause, A. Surov, D. Jechorek, F. Meyer, Z. Halloul; 105. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster (Microsoft Word - DGP2022_Abstractband_Impressum)
Lipoblastoma as a representative example of rare soft tissue tumor lesions in infants with its challenging diagnostic and surgical management
S. Turial, H. Krause, A. Surov, D. Jechorek, F. Meyer, Z. Halloul; 105. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster (Microsoft Word - DGP2022_Abstractband_Impressum)
Paradox inflammatory manifestation of acute appendicitis in anti-inflammtory Januskinase inhibitor-based therapy with Tofacitinib (XeljanzTM) for ulcerative colitis
F. Weber, K. I. Schramm, D. Jechorek, C. March, R. Croner, F. Meyer; 105. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster (Microsoft Word - DGP2022_Abstractband_Impressum)
Long-term survival of a patient with metastatic and recurrent pancreatic acinar cell carcinoma harboring somatic BRCA variants of unknown significance treated with Olaparib maintenance therapy following local treatment
C. Müller, S. Franke, M. J. Powerski, T. B. Brunner, M. Venerito; 35. Deutscher Krebskongress, Berlin (35. Deutscher Krebskongress, Krebsmedizin: Schnittstellen zwischen Innovation und Versorgung, 13.–16. November 2022, Berlin | Oncology Research and Treatment | Karger Publishers)
Multipel rezidivierendes und kurativ wiederholt reseziertes retroperitoneales Liposarkom - 20 Jahre nach Erstdiagnose bei stabiler pathohistologischer Morphe jedoch wechselndem Grading (außergewöhnlicher Fallbericht)
R. Moritz-Tugral, H.-U. Schulz, D. Jechorek, F. Meyer; 35. Deutscher Krebskongress, Berlin (35. Deutscher Krebskongress, Krebsmedizin: Schnittstellen zwischen Innovation und Versorgung, 13.–16. November 2022, Berlin | Oncology Research and Treatment | Karger Publishers)
Prognostic value of keratins and desmosomal proteins in muscle-invasive urothelial carcinoma
A. Scherping, C. Garbers, J. Luzha, M. Schostak, B. Jandrig, A. Hartmann, N. Abele, M. Eckstein, P. Ströbel, B. Tomasik, P. Czapiewski; 34th European Congress of Pathology, Basel, Schweiz (34th European Congress of Pathology - Abstracts | Virchows Archiv | Springer Nature Link)
Ungewöhnliche Diagnose bei Struma multinodosa - isolierte extrapulmonale Manifestation der Sarkoidose in der Schilddrüse (wissenschaftliche Fallberichte)
T. Oksentyuk Polyakova, M. Neumann, F. Meyer, K.I. Schramm, D. Jechorek, R. Croner, M. Petersen; 128. Kongress der Deutschen Gesellschaft für Innere Medizin e.V. (Abstracts zum 128. Kongress der Deutschen Gesellschaft für Innere Medizin e.V. | Die Innere Medizin | Springer Nature Link)
Absorption and migration of tattoo pigments in the human body - tubal factor infertility determined by foreign body reaction in the fallopian tube of tattoo pigments
I. Appel, A. Ignatov, K. Kölble, P. Gennari; 64. Kongress der DGGG (Thieme E-Journals - Geburtshilfe und Frauenheilkunde / Abstract)
2021
Begutachtete Zeitschriftenartikel
Neurogenic inflammation in the context of endometriosis—what do we know?
R.V. Velho, E. Taube, J. Sehouli, S. Mechsner, International Journal of Molecular Sciences 22 (2021). https://doi.org/10.3390/ijms222313102.
A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling
J. Lokau, Y. Garbers, J. Grötzinger, C. Garbers, iScience 24 (2021) 103309. https://doi.org/10.1016/j.isci.2021.103309.
Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury
M. Frissen, L. Liao, K.M. Schneider, S. Djudjaj, J. Haybaeck, A. Wree, U. Rolle-Kampczyk, M. von Bergen, E. Latz, P. Boor, C. Trautwein, Hepatology 73 (2021) 1836–1854. https://doi.org/10.1002/hep.31494.
Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring
S. Breuer, P. Kasper, C. Vohlen, R. Janoschek, T. Hoffmann, S. Appel, E. Müller-Limberger, A. Mesaros, S. Rose-John, C. Garbers, S. Müller, J.-W. Lackmann, E. Mahabir, J. Dötsch, E. Hucklenbruch-Rother, I. Bae-Gartz, Nutrients 13 (2021). https://doi.org/10.3390/nu13113735.
DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status
P. Jurmeister, K. Weber, S. Villegas, T. Karn, M. Untch, A. Thieme, V. Müller, E. Taube, P. Fasching, W.D. Schmitt, F. Marmé, E. Stickeler, B.V. Sinn, P. Jank, C. Schem, F. Klauschen, M. van Mackelenbergh, C. Denkert, S. Loibl, D. Capper, Clinical Epigenetics 13 (2021). https://doi.org/10.1186/s13148-021-01176-5.
GPR Expression in Intestinal Biopsies From SCT Patients Is Upregulated in GvHD and Is Suppressed by Broad-Spectrum Antibiotics
S. Ghimire, D. Weber, K. Hippe, E. Meedt, M. Hoepting, A.-S. Kattner, A. Hiergeist, A. Gessner, C. Matos, S. Ghimire, D. Wolff, M. Edinger, P. Hoffmann, H. Poeck, W. Herr, E. Holler, Front. Immunol. 12 (2021) 753287. https://doi.org/10.3389/fimmu.2021.753287.
Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R
A. Gellrich, F. Scharfenberg, F. Peters, M. Sammel, O. Helm, F. Armbrust, F. Schmidt, J. Lokau, C. Garbers, S. Sebens, P. Arnold, C. Becker-Pauly, Front. Mol. Biosci. 8 (2021) 702341. https://doi.org/10.3389/fmolb.2021.702341.
Diagnostic value of syndecan-4 protein expression in colorectal cancer
D. Jechorek, I. Haeusler-Pliske, F. Meyer, A. Roessner, Pathol. Res. Pract. 222 (2021) 153431. https://doi.org/10.1016/j.prp.2021.153431.
Disruption of Jmjd3/p16Ink4a Signaling Pathway Causes Bizarre Parosteal Osteochondromatous Proliferation (BPOP)-like Lesion in Mice
F. Zhang, Y. Wang, Y. Wang, X. Wang, D. Zhang, X. Zhao, R. Jiang, Y. Gu, G. Yang, X. Fu, L. Xu, L. Xu, L. Zheng, J. Zhang, Z. Li, Q. Yan, J. Shi, A. Roessner, Z. Wang, Q. Li, J. Ye, C.D. Chen, S. Guo, J. Min, J. Bone Miner. Res. 36 (2021) 1931–1941. https://doi.org/10.1002/jbmr.4401.
Dual proteotoxic stress accelerates liver injury via activation of p62-Nrf2
D. Kuscuoglu, L. Bewersdorf, K. Wenzel, A. Gross, G. Kobazi Ensari, Y. Luo, K. Kilic, K. Hittatiya, N. Golob-Schwarzl, R.E. Leube, C. Preisinger, J. George, M. Metwally, M. Eslam, P. Lampertico, S. Petta, A. Mangia, T. Berg, A. Boonstra, W.P. Brouwer, M.L. Abate, A. Loglio, A. Sutton, P. Nahon, B. Schaefer, H. Zoller, E. Aigner, C. Trautwein, J. Haybaeck, P. Strnad, J. Pathol. 254 (2021) 80–91. https://doi.org/10.1002/path.5643.
Eosinophilic pulmonary vasculitis as a manifestation of the hyperinflammatory phase of COVID-19
E. Luecke, A. Jeron, A. Kroeger, D. Bruder, S. Stegemann-Koniszewski, D. Jechorek, K. Borucki, D. Reinhold, A. Reinhold, S. Foellner, T. Walles, T. Hachenberg, J. Schreiber, J. Allergy Clin. Immunol. 147 (2021) 112–113. https://doi.org/10.1016/j.jaci.2020.09.026.
Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma
C. Skofler, F. Kleinegger, S. Krassnig, A.M. Birkl-Toeglhofer, G. Singer, H. Till, M. Benesch, R. Cencic, J.A. Porco, J. Pelletier, C. Castellani, A. Raicht, E. Izycka-Swieszewska, P. Czapiewski, J. Haybaeck, Cells 10 (2021). https://doi.org/10.3390/cells10020301.
An investigation of the diagnostic, predictive, and prognostic impacts of three colonic biopsy grading systems for acute graft versus host disease
A. Kreft, K. Hippe, E.M. Wagner-Drouet, I. Ries, A. Kandulski, M. Büttner-Herold, H. Neumann, D. Weber, E. Holler, M. Schindeldecker, PLoS ONE 16 (2021) e0256543. https://doi.org/10.1371/journal.pone.0256543.
Frequency of actionable molecular drivers in lung cancer patients with precocious brain metastases
B. Hanke, S.T. Jünger, E. Kirches, N. Waldt, J. Schreiber, E. Lücke, S. Franke, I.E. Sandalcioglu, J.-P. Warnke, H.-J. Meisel, J. Prell, C. Scheller, W.E.K. Braunsdorf, M. Preusser, H.-U. Schildhaus, C. Mawrin, Clin. Neurol. Neurosurg. 208 (2021) 106841. https://doi.org/10.1016/j.clineuro.2021.106841.
Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19
C. Garbers, S. Rose-John, Lancet Rheumatol. 3 (2021) e96-e97. https://doi.org/10.1016/S2665-9913(20)30416-1.
Interactome Mapping of eIF3A in a Colon Cancer and an Immortalized Embryonic Cell Line Using Proximity-Dependent Biotin Identification
D.-K. Vo, A. Engler, D. Stoimenovski, R. Hartig, T. Kaehne, T. Kalinski, M. Naumann, J. Haybaeck, N. Nass, Cancers 13 (2021). https://doi.org/10.3390/cancers13061293.
Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling
L. Koch, B. Kespohl, M. Agthe, T. Schumertl, S. Düsterhöft, M.K. Lemberg, J. Lokau, C. Garbers, The FASEB Journal 35 (2021) e21380. https://doi.org/10.1096/fj.202002087R.
Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection
I. Baars, J. Lokau, I. Sauerland, A.J. Müller, C. Garbers, Cytokine 148 (2021) 155699. https://doi.org/10.1016/j.cyto.2021.155699.
Interleukin-6 controls recycling and degradation, but not internalization of its receptors
C.M. Flynn, B. Kespohl, T. Daunke, Y. Garbers, S. Düsterhöft, S. Rose-John, J. Haybaeck, J. Lokau, S. Aparicio-Siegmund, C. Garbers, J. Biol. Chem. 296 (2021) 100434. https://doi.org/10.1016/j.jbc.2021.100434.
Prevalence of human papillomavirus detection in ovarian cancer: a meta-analysis
S. Cherif, A. Amine, S. Thies, E.T. Taube, E.I. Braicu, J. Sehouli, A.M. Kaufmann, European Journal of Clinical Microbiology and Infectious Diseases 40 (2021) 1791–1802. https://doi.org/10.1007/s10096-021-04282-7.
Interleukin-6-interleukin-11 receptor chimeras reveal ionomycin-induced proteolysis beyond ADAM10
J. Lokau, C. Garbers, FEBS Lett. 595 (2021) 3072–3082. https://doi.org/10.1002/1873-3468.14230.
Evaluation of the Aortopathy in the Ascending Aorta: The Novelty of Using Matrix-Assisted Laser Desorption/Ionization Imaging
S.A. Mohamed, E.T. Taube, H. Thiele, F. Noack, G. Nebrich, K. Mohamady, T. Hanke, O. Klein, Proteomics - Clinical Applications 15 (2021). https://doi.org/10.1002/prca.202000047.
MRI-based fat quantification of the liver: Is it time for commercially available products?
S. Hupfeld, D. Pischel, D. Jechorek, A. Janicová, M. Pech, F. Fischbach, Eur. J. Radiol. 144 (2021) 109993. https://doi.org/10.1016/j.ejrad.2021.109993.
Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance
A. Reif, K. Lam, S. Weidler, M. Lott, I. Boos, J. Lokau, C. Bretscher, M. Mönnich, L. Perkams, M. Schmälzlein, C. Graf, J.-P. Fischer, C. Lechner, K. Hallstein, S. Becker, M. Weyand, C. Steegborn, G. Schultheiss, S. Rose-John, C. Garbers, C. Unverzagt, Angew. Chem. Int. Ed Engl. 60 (2021) 13380–13387. https://doi.org/10.1002/anie.202101496.
New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology
M.D. Giraldez, D. Carneros, C. Garbers, S. Rose-John, M. Bustos, Nat. Rev. Gastroenterol. Hepatol. 18 (2021) 787–803. https://doi.org/10.1038/s41575-021-00473-x.
Perturbation of the Actin Cytoskeleton in Human Hepatoma Cells Influences Interleukin-6 (IL-6) Signaling, but Not Soluble IL-6 Receptor Generation or NF-κB Activation
E. Georgieva, S.L. Leber, C. Wex, C. Garbers, International Journal of Molecular Sciences 22 (2021). https://doi.org/10.3390/ijms22137171.
The cytokine interleukin-11 crucially links bone formation, remodeling and resorption
B. Kespohl, T. Schumertl, J. Bertrand, J. Lokau, C. Garbers, Cytokine Growth Factor Rev. 60 (2021) 18–27. https://doi.org/10.1016/j.cytogfr.2021.04.002.
The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis
J.-H. Maiwald, S. Sprung, P. Czapiewski, W. Lessel, A. Scherping, D. Schomburg, M. Plaumann, B. Tomasik, G. Behre, J. Haybaeck, A. Ignatov, H. Eggemann, N. Nass, Contemp. Oncol. (Pozn) 25 (2021) 204–212. https://doi.org/10.5114/wo.2021.110010.
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release
S. Düsterhöft, S. Kahveci-Türköz, J. Wozniak, A. Seifert, P. Kasparek, H. Ohm, S. Liu, J. Kopkanova, J. Lokau, C. Garbers, C. Preisinger, R. Sedlacek, M. Freeman, A. Ludwig, Cell. Mol. Life Sci. 78 (2021) 5015–5040. https://doi.org/10.1007/s00018-021-03845-3.
The predictive potential of Neuronatin for neoadjuvant chemotherapy of breast cancer
W. Pieper, A. Ignatov, T. Kalinski, J. Haybaeck, P. Czapiewski, N. Nass, Cancer Biomark. 32 (2021) 161–173. https://doi.org/10.3233/CBM-203127.
Classification of molecular subtypes of high-grade serous ovarian cancer by maldi-imaging
W. Kassuhn, O. Klein, S. Darb-Esfahani, H. Lammert, S. Handzik, E.T. Taube, W.D. Schmitt, C. Keunecke, D. Horst, F. Dreher, J. George, D.D. Bowtell, O. Dorigo, M. Hummel, J. Sehouli, N. Blüthgen, H. Kulbe, E.I. Braicu, Cancers 13 (2021). https://doi.org/10.3390/cancers13071512.
The prevalence of DNA microsatellite instability in anaplastic thyroid carcinoma - systematic review and discussion of current therapeutic options
M.L. Rocha, K.W. Schmid, P. Czapiewski, Contemp. Oncol. (Pozn) 25 (2021) 213–223. https://doi.org/10.5114/wo.2021.110052.
The role of calcium crystals and their effect on osteoarthritis pathogenesis
S. Stücker, M. Bollmann, C. Garbers, J. Bertrand, Best Pract. Res. Clin. Rheumatol. 35 (2021) 101722. https://doi.org/10.1016/j.berh.2021.101722.
When and how should peritoneal endometriosis be operated on in order to improve fertility rates and symptoms? The experience and outcomes of nearly 100 cases
A.M. Dückelmann, E. Taube, E. Abesadze, V. Chiantera, J. Sehouli, S. Mechsner, Archives of Gynecology and Obstetrics 304 (2021) 143–155. https://doi.org/10.1007/s00404-021-05971-6.
Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease
S. Schreiber, K. Aden, J.P. Bernardes, C. Conrad, F. Tran, H. Höper, V. Volk, N. Mishra, J.I. Blase, S. Nikolaus, J. Bethge, T. Kühbacher, C. Röcken, M. Chen, I. Cottingham, N. Petri, B.B. Rasmussen, J. Lokau, L. Lenk, C. Garbers, F. Feuerhake, S. Rose-John, G.H. Waetzig, P. Rosenstiel, Gastroenterology 160 (2021) 2354-2366.e11. https://doi.org/10.1053/j.gastro.2021.02.062.
Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice
L.M. Westermann, A. Baranowsky, G. Di Lorenzo, T. Danyukova, J. Soul, J.-M. Schwartz, G. Hendrickx, M. Amling, S. Rose-John, C. Garbers, T. Schinke, S. Pohl, Sci Rep 11 (2021) 3556. https://doi.org/10.1038/s41598-021-82802-3.
Translational cell biology of highly malignant osteosarcoma[KF11]
A. Roessner, C. Lohmann, D. Jechorek, Pathol. Int. 71 (2021) 291–303. https://doi.org/10.1111/pin.13080.
Lymphovascular space invasion and Ki67 as predictors of lymph node metastasis in primary low grade serous ovarian cancer
J.P. Grabowski, J. Glajzer, R. Richter, H. Plett, M.-Z. Muallem, E.I. Braicu, E. Taube, J. Sehouli, International Journal of Gynecological Cancer 31 (2021) 98–103. https://doi.org/10.1136/ijgc-2020-001950.